SMAD7 and AXIN1

Data Source:
HPRD (in vitro, in vivo)

		SMAD7	AXIN1
Description		SMAD family member 7	axin 1
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Catenin Complex Protein-containing Complex Heteromeric SMAD Protein Complex	Nucleus Cytoplasm Cytosol Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	DNA Binding Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding Activin Binding I-SMAD Binding Transcription Regulator Inhibitor Activity	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein-containing Complex Localization Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation	Positive Regulation Of Protein Phosphorylation Apoptotic Process Multicellular Organism Development Positive Regulation Of Peptidyl-threonine Phosphorylation Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs			1,4-Dithiothreitol
Diseases			Hepatocellular carcinoma Caudal duplication anomaly
GWAS		Asthma ( 32296059) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 25990418 18372901 18372905 30529582 21761138 17934461 26151821 29228715 30104761 24836286 29471430 24448986 31826910 23266556) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252)	Adult body size ( 32376654) Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Waist circumference ( 31928498)
Interacting Genes		59 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L OTUD1 PARD3 PIAS1 PIAS4 RLIM RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	83 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TP53 TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSGA10 USP7 UTP14A ZBTB26 ZFYVE19
Entrez ID		4092	8312
HPRD ID		04241	04819
Ensembl ID		ENSG00000101665	ENSG00000103126
Uniprot IDs		B3KYA8 O15105	A0A0S2Z4R0 A0A0S2Z4S3 O15169
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ	1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ 6JCK
Enriched GO Terms of Interacting Partners?
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