SMAD7 and STAMBP

Data Source:
HPRD (in vivo)

		SMAD7	STAMBP
Description		SMAD family member 7	STAM binding protein
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Catenin Complex Protein-containing Complex Heteromeric SMAD Protein Complex	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding Activin Binding I-SMAD Binding Transcription Regulator Inhibitor Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein-containing Complex Localization Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation	Mitotic Cytokinesis Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases	Metalloprotease DUBs
Drugs
Diseases
GWAS		Asthma ( 32296059) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 25990418 18372901 18372905 30529582 21761138 17934461 26151821 29228715 30104761 24836286 29471430 24448986 31826910 23266556) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252)	Anti-saccade response ( 29064472) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944)
Interacting Genes		59 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L OTUD1 PARD3 PIAS1 PIAS4 RLIM RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	45 interacting genes: ALAS1 AMN APOBEC3A BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP3 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28
Entrez ID		4092	10617
HPRD ID		04241	05877
Ensembl ID		ENSG00000101665	ENSG00000124356
Uniprot IDs		B3KYA8 O15105	A0A140VK54 O95630
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ	2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?
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