POLE2 and SORBS3

Data Source:
BioGRID (two hybrid)

		POLE2	SORBS3
Description		DNA polymerase epsilon 2, accessory subunit	sorbin and SH3 domain containing 3
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GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Smooth Muscle Contraction
Drugs		Cladribine
Diseases
GWAS			Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	133 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AKIRIN2 AKT2 ANKS1A ARNT2 C1orf109 CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM214B FAM53C FASLG FBXL19 FLOT1 FNDC11 GAS8 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		5427	10174
HPRD ID		16007	11535
Ensembl ID		ENSG00000100479	ENSG00000120896
Uniprot IDs		P56282	O60504
PDB IDs		2V6Z 5VBN	2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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