SORBS3 and CCNL1

Data Source:
BioGRID (two hybrid)

		SORBS3	CCNL1
Description		sorbin and SH3 domain containing 3	cyclin L1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Nucleus Nuclear Speck
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II RNA Processing
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Adiponectin levels in pregnancy ( 28317342) Adult body size ( 32376654) Anthropometric traits in newborns ( 23575227) Birth weight ( 23202124 31453325 31043758 27680694 20372150) Birth weight variance ( 31453325) Body fat percentage variance ( 31453325) Body mass index ( 26426971) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 32917775 26833098) Coronary artery disease ( 33020668) Diabetic retinopathy ( 21441570) Eating disorders ( 22911880) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Menarche (age at onset) ( 25231870) Offspring birth weight ( 31043758) PR interval ( 30046033 32439900) Smoking cessation in chronic obstructive pulmonary disease ( 21685187)
Interacting Genes		133 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AKIRIN2 AKT2 ANKS1A ARNT2 C1orf109 CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM214B FAM53C FASLG FBXL19 FLOT1 FNDC11 GAS8 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	22 interacting genes: APP APPBP2 C1orf35 CASP8 CDK11A DVL3 FAM133A JMJD6 KRTAP12-2 NKAPD1 PRDM6 PRPF40A RAD51D RNPS1 RSRP1 SAP30BP SORBS3 SREK1IP1 SRSF2 TFIP11 ZRANB1 ZRSR2
Entrez ID		10174	57018
HPRD ID		11535	10814
Ensembl ID		ENSG00000120896	ENSG00000163660
Uniprot IDs		O60504	Q9UK58
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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