SORBS3 and INSC

Data Source:
BioGRID (two hybrid)

		SORBS3	INSC
Description		sorbin and SH3 domain containing 3	INSC spindle orientation adaptor protein
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Plasma Membrane Cell Cortex Protein-containing Complex Apical Cortex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Establishment Of Mitotic Spindle Orientation Nervous System Development Asymmetric Cell Division Regulation Of Asymmetric Cell Division Cell Differentiation Regulation Of Protein Stability Apical Protein Localization
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Expressive vocabulary in infants ( 25226531) Heel bone mineral density ( 30598549 28869591) Menarche (age at onset) ( 23667675) Obesity-related traits ( 23251661)
Interacting Genes		133 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AKIRIN2 AKT2 ANKS1A ARNT2 C1orf109 CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM214B FAM53C FASLG FBXL19 FLOT1 FNDC11 GAS8 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	17 interacting genes: CCDC187 GEM GPANK1 GPSM1 GPSM2 LHX3 LNX1 PARD3 PARD3B PRR35 RUSC1 SMARCD1 SORBS3 TEKT3 TTC23 USP54 ZNF587
Entrez ID		10174	387755
HPRD ID		11535	18803
Ensembl ID		ENSG00000120896	ENSG00000188487
Uniprot IDs		O60504	Q1MX18
PDB IDs		2CT3 2DLM 2NWM 2YUP	3SF4
Enriched GO Terms of Interacting Partners?
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