SORBS3 and GPANK1

Data Source:
BioGRID (two hybrid)

		SORBS3	GPANK1
Description		sorbin and SH3 domain containing 3	G-patch domain and ankyrin repeats 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Nucleic Acid Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Febrile seizures (MMR vaccine-related) ( 25344690) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)
Interacting Genes		133 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AKIRIN2 AKT2 ANKS1A ARNT2 C1orf109 CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM214B FAM53C FASLG FBXL19 FLOT1 FNDC11 GAS8 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	89 interacting genes: ABI2 AKAP8L ANAPC11 AP1B1 AP2B1 APP BAG4 BHLHB9 C1QTNF2 CADPS CCDC184 CCDC33 CCDC85B CEACAM6 CYSRT1 DDI1 DHX15 DISC1 ECM1 EFS FAM166B FTO GOLGA2 GOLGA6L9 GRB2 HNRNPH1 HOMEZ HSF2BP HYI INKA1 INSC KANK2 KATNBL1 KCTD9 KRT75 KRTAP10-8 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP19-6 LDOC1 LIG4 LZTS2 MAGED1 MAGOHB MDFI MEOX1 MEOX2 METTL27 METTL6 MID2 MORN3 NADSYN1 NFKBID NR1H3 NUTM1 OIP5 PATZ1 PAX6 PBX4 PFDN5 PLAAT1 PNMA1 PPARA PPP4C PRDM6 PTH1R RIMBP3C RTL8C SORBS3 SPATA2 STMN3 STX5 TEPSIN TFCP2 TLE5 TRAF2 TRAPPC2L TRIM23 TRIM27 TSC1 TTC19 TTC23 VBP1 ZBTB16 ZBTB8OS ZMAT5 ZNF688 ZRANB1
Entrez ID		10174	7918
HPRD ID		11535	00810
Ensembl ID		ENSG00000120896	ENSG00000204438
Uniprot IDs		O60504	A0A024RCU2 B2RA66 O95872
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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