POLD4 and SEC23IP

Data Source:
HPRD (in vitro, two hybrid)

		POLD4	SEC23IP
Description		DNA polymerase delta 4, accessory subunit	SEC23 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Delta DNA Polymerase Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding	RNA Binding Phospholipase Activity Protein Binding Metal Ion Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage	Intracellular Protein Transport Golgi Organization COPII Vesicle Coating
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Cerebrospinal fluid clusterin levels ( 26545630) HDL cholesterol levels ( 32203549) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870)
Interacting Genes		9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1	7 interacting genes: HSPB11 PCNA POLD4 SEC23A SSC5D WWOX YIF1A
Entrez ID		57804	11196
HPRD ID		17873	07152
Ensembl ID		ENSG00000175482	ENSG00000107651
Uniprot IDs		A0A024R5D7 Q6NSD7 Q9HCU8	Q9Y6Y8
PDB IDs		6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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