POLD1 and POLD3

Data Source:
HPRD (in vivo)

		POLD1	POLD3
Description		DNA polymerase delta 1, catalytic subunit	DNA polymerase delta 3, accessory subunit
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex	Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Cellular Response To UV DNA Damage Response, Detection Of DNA Damage DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)	Colorectal cancer ( 22634755 25990418 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29691431 29313844) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)
Interacting Genes		22 interacting genes: ADAMTSL4 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLD2 POLD3 POLD4 SUMO2 TERF2IP TREX2 TRIM55 WRNIP1 XRCC5 YPEL3	8 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1 SPRTN
Entrez ID		5424	10714
HPRD ID		08882	11446
Ensembl ID		ENSG00000062822	ENSG00000077514
Uniprot IDs		A0A024R4F4 A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0	A0A024R5M8 Q15054
PDB IDs		6S1M 6S1N 6S1O 6TNY 6TNZ	1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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