SOX10 and DLX5

Data Source:
HPRD (in vitro, two hybrid)

		SOX10	DLX5
Description		SRY-box transcription factor 10	distal-less homeobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Extrinsic Component Of Mitochondrial Outer Membrane	Chromatin Nucleus Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Melanocyte Differentiation Positive Regulation Of Myelination Lacrimal Gland Development Cellular Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Population Proliferation Embryo Development Olfactory Bulb Interneuron Differentiation Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Olfactory Pit Development Face Morphogenesis Cellular Response To BMP Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Interneuron Axon Guidance Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination	Regulation of RUNX2 expression and activity
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Waardenburg syndrome (WS)
GWAS		Mean spheric corpuscular volume ( 32888494)	Heel bone mineral density ( 30598549 28869591) Morning vs. evening chronotype ( 26835600)
Interacting Genes		35 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX DAZAP2 DLX5 EGR2 EXOC5 GSK3B HHEX HIVEP1 HOXA3 HOXC4 HSF4 JUN MAGED1 MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1	9 interacting genes: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN
Entrez ID		6663	1749
HPRD ID		03752	02492
Ensembl ID		ENSG00000100146	ENSG00000105880
Uniprot IDs		A0A024R1N6 P56693	P56178 Q53Y73
PDB IDs			2DJN 4RDU
Enriched GO Terms of Interacting Partners?
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