SOX10 and PAX3

Data Source:
BioGRID (pull down, affinity chromatography technology, genetic interference)
HPRD (in vivo, in vitro)

		SOX10	PAX3
Description		SRY-box transcription factor 10	paired box 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Extrinsic Component Of Mitochondrial Outer Membrane	Chromatin Nucleoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Melanocyte Differentiation Positive Regulation Of Myelination Lacrimal Gland Development Cellular Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Muscle Organ Development Sensory Perception Of Sound Animal Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination	HATs acetylate histones
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Waardenburg syndrome (WS)	Alveolar rhabdomyosarcoma Craniofacial-deafness-hand syndrome Waardenburg syndrome (WS)
GWAS		Mean spheric corpuscular volume ( 32888494)	Adolescent idiopathic scoliosis ( 26394188) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132) Facial morphology ( 31763980 22341974) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Information processing speed ( 25869804) Male-pattern baldness ( 28196072) middle facial morphology traits (quantitative measurement) ( 27193062) Monobrow ( 27182965) Monobrow thickness ( 26926045) Nose size ( 27182965) Vitamin D levels ( 25208829) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		35 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX DAZAP2 DLX5 EGR2 EXOC5 GSK3B HHEX HIVEP1 HOXA3 HOXC4 HSF4 JUN MAGED1 MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1	18 interacting genes: CIB1 DAXX FZR1 HDAC10 IPO13 KRTAP6-2 KRTAP8-1 MEOX1 MEOX2 MITF MSX1 POU3F2 RAD23B SOX10 SOX8 TAF1 TBP WWTR1
Entrez ID		6663	5077
HPRD ID		03752	09421
Ensembl ID		ENSG00000100146	ENSG00000135903
Uniprot IDs		A0A024R1N6 P56693	P23760
PDB IDs			3CMY
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?