PITPNA and PI4KA

Data Source:
HPRD (in vivo)

		PITPNA	PI4KA
Description		phosphatidylinositol transfer protein alpha	phosphatidylinositol 4-kinase alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Viral Replication Complex Golgi-associated Vesicle Membrane Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Phosphatidylcholine Transfer Activity Phosphatidylglycerol Binding	1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Kinase Activity Cadherin Binding Phosphatidylinositol Kinase Activity
	Biological Process	Lipid Metabolic Process Visual Perception Phospholipid Transport Interleukin-12-mediated Signaling Pathway Intermembrane Lipid Transfer	Phosphatidylinositol Biosynthetic Process Signal Transduction Phosphorylation Viral RNA Genome Replication Multi-organism Membrane Organization Viral Replication Complex Formation And Maintenance Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling
Pathways		Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs		1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Diseases
GWAS		Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Fulminant type 1 diabetes ( 30552108) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes		8 interacting genes: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2	10 interacting genes: C8orf33 CD4 CD7 LCK MRPL44 MTNR1B PITPNA SNX9 STRN4 TNNT1
Entrez ID		5306	5297
HPRD ID		02548	08972
Ensembl ID		ENSG00000174238	ENSG00000241973
Uniprot IDs		Q00169 V9HWC5	B4DYG5 P42356 Q4LE69
PDB IDs		1UW5	6BQ1
Enriched GO Terms of Interacting Partners?
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