PI4KA and PITPNA

Data Source:
HPRD (in vivo)

		PI4KA	PITPNA
Description		phosphatidylinositol 4-kinase alpha	phosphatidylinositol transfer protein alpha
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Viral Replication Complex Golgi-associated Vesicle Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Kinase Activity Cadherin Binding Phosphatidylinositol Kinase Activity	Protein Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Phosphatidylcholine Transfer Activity Phosphatidylglycerol Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Phosphorylation Viral RNA Genome Replication Multi-organism Membrane Organization Viral Replication Complex Formation And Maintenance Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling	Lipid Metabolic Process Visual Perception Phospholipid Transport Interleukin-12-mediated Signaling Pathway Intermembrane Lipid Transfer
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane	Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Diseases
GWAS		Fulminant type 1 diabetes ( 30552108) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)	Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		10 interacting genes: C8orf33 CD4 CD7 LCK MRPL44 MTNR1B PITPNA SNX9 STRN4 TNNT1	8 interacting genes: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2
Entrez ID		5297	5306
HPRD ID		08972	02548
Ensembl ID		ENSG00000241973	ENSG00000174238
Uniprot IDs		B4DYG5 P42356 Q4LE69	Q00169 V9HWC5
PDB IDs		6BQ1	1UW5
Enriched GO Terms of Interacting Partners?
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