PITPNA and PIK3C3

Data Source:
HPRD (in vitro, in vivo)

		PITPNA	PIK3C3
Description		phosphatidylinositol transfer protein alpha	phosphatidylinositol 3-kinase catalytic subunit type 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome
	Molecular Function	Protein Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Phosphatidylcholine Transfer Activity Phosphatidylglycerol Binding	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity
	Biological Process	Lipid Metabolic Process Visual Perception Phospholipid Transport Interleukin-12-mediated Signaling Pathway Intermembrane Lipid Transfer	Autophagosome Assembly Protein Lipidation Phosphatidylinositol Biosynthetic Process Endocytosis Autophagy Cell Cycle Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Toll-like Receptor 9 Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Cell Division
Pathways		Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs		1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide	N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
Diseases
GWAS		Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Adult body size ( 32376654) Blood trace element (Zn levels) ( 23720494) Body size at age 10 ( 32376654) General risk tolerance (MTAG) ( 30643258) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966)
Interacting Genes		8 interacting genes: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2	8 interacting genes: CALM1 CASP8 FBXL20 PIK3R4 PITPNA STYK1 YWHAG YWHAQ
Entrez ID		5306	5289
HPRD ID		02548	04009
Ensembl ID		ENSG00000174238	ENSG00000078142
Uniprot IDs		Q00169 V9HWC5	A8MYT4 B4DPV9 Q8NEB9
PDB IDs		1UW5	3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U
Enriched GO Terms of Interacting Partners?
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