SERPINB5 and ATIC

Data Source:
BioGRID (two hybrid)

		SERPINB5	ATIC
Description		serpin family B member 5	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity Cadherin Binding
	Biological Process	Morphogenesis Of An Epithelium Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis	Brainstem Development Nucleobase-containing Compound Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Cellular Response To Interleukin-7
Pathways			Purine ribonucleoside monophosphate biosynthesis
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine	Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
Diseases			AICA-ribosiduria; ATIC deficiency
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)	Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF SMAD4 STK11 TBP TKT UCHL5 XRCC3	5 interacting genes: EGFR LINC01554 MTNR1A PRNP SERPINB5
Entrez ID		5268	471
HPRD ID		01111	03434
Ensembl ID		ENSG00000206075	ENSG00000138363
Uniprot IDs		A0A024R2B6 P36952	P31939 V9HWH7
PDB IDs		1WZ9 1XQG 1XQJ 1XU8	1P4R 1PKX 1PL0 5UY8 5UZ0
Enriched GO Terms of Interacting Partners?
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