PDGFRL and MAPK12

Data Source:
BioGRID (two hybrid)

		PDGFRL	MAPK12
Description		platelet derived growth factor receptor like	mitogen-activated protein kinase 12
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Region	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Biological_process Platelet-derived Growth Factor Receptor-beta Signaling Pathway	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation
Pathways			NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs			Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510	29 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		5157	6300
HPRD ID		05206	03868
Ensembl ID		ENSG00000104213	ENSG00000188130
Uniprot IDs		Q15198	P53778 Q6N076
PDB IDs			1CM8 4QUM 6UNA
Enriched GO Terms of Interacting Partners?
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