PDGFRL and XPA

Data Source:
BioGRID (two hybrid)

		PDGFRL	XPA
Description		platelet derived growth factor receptor like	XPA, DNA damage recognition and repair factor
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Region	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Intercellular Bridge
	Molecular Function	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Biological_process Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion UV Protection Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus Global Genome Nucleotide-excision Repair UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways			Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510	51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC4 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		5157	7507
HPRD ID		05206	02045
Ensembl ID		ENSG00000104213	ENSG00000136936
Uniprot IDs		Q15198	P23025
PDB IDs			1D4U 1XPA 2JNW 6J44 6LAE 6RO4
Enriched GO Terms of Interacting Partners?
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