MAPK12 and EEF2K

Data Source:
HPRD (in vitro)

		MAPK12	EEF2K
Description		mitogen-activated protein kinase 12	eukaryotic elongation factor 2 kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding
	Biological Process	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation	Response To Ischemia Translational Elongation Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin
Pathways		NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway	mTORC1-mediated signalling
Drugs		Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)	Heel bone mineral density ( 30598549)
Interacting Genes		29 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2
Entrez ID		6300	29904
HPRD ID		03868	07369
Ensembl ID		ENSG00000188130	ENSG00000103319
Uniprot IDs		P53778 Q6N076	O00418
PDB IDs		1CM8 4QUM 6UNA	5J8H 5KS5 6NX4
Enriched GO Terms of Interacting Partners?
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