MAPK12 and DLG1

Data Source:
HPRD (in vitro)

		MAPK12	DLG1
Description		mitogen-activated protein kinase 12	discs large MAGUK scaffold protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Immunological Synapse Basement Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Bicellular Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Neuron Projection Lateral Loop Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome MPP7-DLG1-LIN7 Complex Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Ion Channel Binding Cadherin Binding Molecular Adaptor Activity L27 Domain Binding Structural Constituent Of Postsynaptic Density
	Biological Process	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye Protein Dephosphorylation Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Embryo Development Viral Process Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Astral Microtubule Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity Cellular Protein-containing Complex Localization T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Cortical Microtubule Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Negative Regulation Of ERK1 And ERK2 Cascade Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Postsynaptic Density Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of NIK/NF-kappaB Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Localization To Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Import Negative Regulation Of P38MAPK Cascade Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of NMDA Receptor Activity
Pathways		NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway	Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)	Allergic rhinitis ( 25085501) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) PR interval ( 32439900)
Interacting Genes		29 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	75 interacting genes: ACTA1 ACTN2 ADAM17 ADGRA2 ADGRA3 ADGRB1 ADRB1 AKAP5 ATP2B2 ATP2B4 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRHR1 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GRIA1 GRIK2 GRIN1 GRIN2A GRIN2B GUCY1A2 HTR2A KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PAX6 PBK PRKN PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A
Entrez ID		6300	1739
HPRD ID		03868	03007
Ensembl ID		ENSG00000188130	ENSG00000075711
Uniprot IDs		P53778 Q6N076	A0A0C4DFT3 A0A590UJ08 B4DF78 Q12959
PDB IDs		1CM8 4QUM 6UNA	1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?
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