UFD1 and MASP1

Data Source:
BioGRID (two hybrid)

		UFD1	MASP1
Description		ubiquitin recognition factor in ER associated degradation 1	MBL associated serine protease 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex	Extracellular Region Extracellular Space Nucleoplasm Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation
Pathways		Translesion Synthesis by POLH Ub-specific processing proteases	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)
Interacting Genes		23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP	16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1
Entrez ID		7353	5648
HPRD ID		06778	02749
Ensembl ID		ENSG00000070010	ENSG00000127241
Uniprot IDs		Q541A5 Q92890	F8W876 P48740
PDB IDs		2YUJ 5B6C 5C1B	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD
Enriched GO Terms of Interacting Partners?
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