SNX9 and PAK2

Data Source:
HPRD (in vitro)

		SNX9	PAK2
Description		sorting nexin 9	p21 (RAC1) activated kinase 2
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Cuticular Plate Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Membrane Organization Protein-containing Complex Assembly Plasma Membrane Tubulation	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Phosphorylation Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Adherens Junction Assembly Interleukin-12-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Dendritic Spine Development Positive Regulation Of Protein Tyrosine Kinase Activity Bicellular Tight Junction Assembly Cellular Response To Organic Cyclic Compound Protein Localization To Cell-cell Junction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Fostamatinib
Diseases
GWAS		Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252)	Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte counts ( 32888494 27863252) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 32888494 27863252)
Interacting Genes		23 interacting genes: ADAM15 ADAM9 AP1G1 CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MPHOSPH6 PAK2 PALS2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL	54 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NCK2 NPHP1 PACSIN3 PPM1A RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		51429	5062
HPRD ID		12072	05428
Ensembl ID		ENSG00000130340	ENSG00000180370
Uniprot IDs		Q9Y5X1	A8K5M4 Q13177
PDB IDs		2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE	3PCS
Enriched GO Terms of Interacting Partners?
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