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PAK2 and RPS6
Data Source:
HPRD
(in vitro)
PAK2
RPS6
Description
p21 (RAC1) activated kinase 2
ribosomal protein S6
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Postsynaptic Density
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Nucleus
Nucleoplasm
Nucleolus
Endoplasmic Reticulum
Cytosol
Polysome
Small Ribosomal Subunit
Membrane
Cytosolic Small Ribosomal Subunit
Dendrite
Cytoplasmic Ribonucleoprotein Granule
Cell Body
Perinuclear Region Of Cytoplasm
Ribonucleoprotein Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Protein Kinase Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Phosphorylation
Peptidyl-serine Phosphorylation
Stress-activated Protein Kinase Signaling Cascade
T Cell Costimulation
Activation Of Protein Kinase Activity
Adherens Junction Assembly
Interleukin-12-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Growth
Negative Regulation Of Apoptotic Process
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Axonogenesis
T Cell Receptor Signaling Pathway
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Dendritic Spine Development
Positive Regulation Of Protein Tyrosine Kinase Activity
Bicellular Tight Junction Assembly
Cellular Response To Organic Cyclic Compound
Protein Localization To Cell-cell Junction
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
G1/S Transition Of Mitotic Cell Cycle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Placenta Development
T Cell Proliferation Involved In Immune Response
RRNA Processing
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Activation-induced Cell Death Of T Cells
Gastrulation
Positive Regulation Of Cell Population Proliferation
Viral Transcription
Mammalian Oogenesis Stage
TOR Signaling
T Cell Differentiation In Thymus
Ribosomal Small Subunit Biogenesis
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Erythrocyte Development
Pathways
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
mTORC1-mediated signalling
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Fostamatinib
Artenimol
Diseases
GWAS
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil counts (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte counts (
32888494
27863252
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
27863252
)
Neutrophil count (
32888494
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
32888494
27863252
)
Total cholesterol levels (
29083408
)
Interacting Genes
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
DOCK2
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NCK2
NPHP1
PACSIN3
PPM1A
RAC1
RAC2
RAF1
RHOJ
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
16 interacting genes:
ATF4
DUX4
ERCC6
FRS2
MYOM2
NDRG1
OLFM2
PAK2
PLA2G12A
PRKACB
PRKCSH
PTEN
RPS6KB1
RPS6KB2
STAU1
UPF2
Entrez ID
5062
6194
HPRD ID
05428
01592
Ensembl ID
ENSG00000180370
ENSG00000137154
Uniprot IDs
A8K5M4
Q13177
A2A3R6
P62753
PDB IDs
3PCS
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6EK0
6F4P
6F4Q
6FEC
6G18
6G4S
6G4W
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBW
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOK
6ZON
6ZP4
6ZVH
6ZVJ
7A09
7K5I
Enriched GO Terms of Interacting Partners
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