ZBTB7A and CRBN

Data Source:
BioGRID (pull down)

		ZBTB7A	CRBN
Description		zinc finger and BTB domain containing 7A	cereblon
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GO Annotations	Cellular Component	Nucleus Cytoplasm NuRD Complex Site Of Double-strand Break DNA-dependent Protein Kinase Complex	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding SMAD Binding Metal Ion Binding Androgen Receptor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Glycolytic Process Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Apoptotic Process Erythrocyte Maturation Fat Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Androgen Receptor Signaling Pathway Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Transcription Regulatory Region DNA Binding	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Potential therapeutics for SARS
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Adult body size ( 32376654) Chronic lymphocytic leukemia ( 28165464) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pulse pressure ( 30578418) Reaction time ( 29844566) Red blood cell count ( 32888494 27863252)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		19 interacting genes: AR BCL6 CRBN HOMEZ KHDRBS1 MBD3 NCOR1 NCOR2 PRKDC RELA SMAD4 SP1 SP3 SP4 UBE2I XRCC5 XRCC6 ZBTB48 ZMYND8	36 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		51341	51185
HPRD ID		10433	16750
Ensembl ID		ENSG00000178951	ENSG00000113851
Uniprot IDs		O95365	Q96SW2
PDB IDs		2IF5 2NN2	4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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