GMNN and HOXD10

Data Source:
HPRD (in vitro)

		GMNN	HOXD10
Description		geminin DNA replication inhibitor	homeobox D10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	Regulation Of Transcription By RNA Polymerase II Single Fertilization Skeletal Muscle Tissue Development Adult Locomotory Behavior Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Embryonic Limb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Peripheral Nervous System Neuron Development Neuromuscular Process
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs
Diseases			Congenital vertical talus
GWAS		Metabolite levels ( 23823483)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462) Male-pattern baldness ( 28196072)
Interacting Genes		34 interacting genes: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF250 ZNF439	7 interacting genes: CREBBP EP300 GEMIN2 GMNN HMGB1 PBX1 RCHY1
Entrez ID		51053	3236
HPRD ID		06783	00867
Ensembl ID		ENSG00000112312	ENSG00000128710
Uniprot IDs		A0A024QZY7 O75496	P28358
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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