GMNN and SCMH1

Data Source:
HPRD (in vitro)

		GMNN	SCMH1
Description		geminin DNA replication inhibitor	Scm polycomb group protein homolog 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Chromocenter
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	Chromatin Binding Protein Binding Histone Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	Chromatin Remodeling Spermatogenesis Anterior/posterior Pattern Specification Gene Silencing Negative Regulation Of Transcription, DNA-templated
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs			Mercaptoethanol
Diseases
GWAS		Metabolite levels ( 23823483)	Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737 29892015) General risk tolerance (MTAG) ( 30643258) Height ( 20881960 25282103 23563607 18391952) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435)
Interacting Genes		34 interacting genes: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF250 ZNF439	19 interacting genes: EWSR1 GMNN HK1 HPCAL4 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M SFMBT1 SFMBT2 TMEM11 TOB1 UBQLN1 UBQLN4
Entrez ID		51053	22955
HPRD ID		06783	11540
Ensembl ID		ENSG00000112312	ENSG00000010803
Uniprot IDs		A0A024QZY7 O75496	B3KMZ7 Q96GD3
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY	2P0K
Enriched GO Terms of Interacting Partners?
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