GMNN and HOXA11

Data Source:
HPRD (in vitro)

		GMNN	HOXA11
Description		geminin DNA replication inhibitor	homeobox A11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	Skeletal System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Single Fertilization Mesodermal Cell Fate Specification Male Gonad Development Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Positive Regulation Of Cell Development Embryonic Limb Morphogenesis Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Transcription, DNA-templated Developmental Growth Anatomical Structure Development Uterus Development Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs
Diseases			Radioulnar synostosis with amegakaryocytic thrombocytopenia
GWAS		Metabolite levels ( 23823483)	Heel bone mineral density ( 30598549 28869591) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		34 interacting genes: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF250 ZNF439	5 interacting genes: CREBBP GMNN MEIS1 PGBD3 YY1
Entrez ID		51053	3207
HPRD ID		06783	00846
Ensembl ID		ENSG00000112312	ENSG00000005073
Uniprot IDs		A0A024QZY7 O75496	P31270
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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