GMNN and HOXA10

Data Source:
HPRD (in vitro)

		GMNN	HOXA10
Description		geminin DNA replication inhibitor	homeobox A10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Uterus Development
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs			Calcitriol
Diseases
GWAS		Metabolite levels ( 23823483)	Dental caries ( 23259602) Hypertension ( 31879980 30487518) Mean arterial pressure ( 30487518)
Interacting Genes		34 interacting genes: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF250 ZNF439	13 interacting genes: CREBBP EMX1 EP300 FOXO1 GMNN GNG13 MEIS1 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1
Entrez ID		51053	3206
HPRD ID		06783	00845
Ensembl ID		ENSG00000112312	ENSG00000253293
Uniprot IDs		A0A024QZY7 O75496	P31260
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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