KHSRP and PTBP2

Data Source:
BioGRID (pull down)

		KHSRP	PTBP2
Description		KH-type splicing regulatory protein	polypyrimidine tract binding protein 2
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GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding	RNA Binding MRNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Gene Expression MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus	MRNA Splice Site Selection Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs		Resveratrol Artenimol
Diseases
GWAS			Adult body size ( 32376654) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398 30944420) Waist circumference ( 25673412)
Interacting Genes		14 interacting genes: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 KLHL12 PARN PTBP2 STK3 UBE2I	19 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA TOM1
Entrez ID		8570	58155
HPRD ID		10350	12233
Ensembl ID		ENSG00000088247	ENSG00000117569
Uniprot IDs		Q92945	A0A6Q8PFE6 B4DSS8 B4DSU5 Q9UKA9
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2CQ1 2MJU 4CQ1
Enriched GO Terms of Interacting Partners?
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