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ORC1 and ORC2
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
ORC1
ORC2
Description
origin recognition complex subunit 1
origin recognition complex subunit 2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Cytosol
Chromosome, Telomeric Region
Heterochromatin
Origin Recognition Complex
Condensed Chromosome Inner Kinetochore
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Centrosome
Membrane
Molecular Function
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
ATPase Activity
Metal Ion Binding
DNA Replication Origin Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Mitotic DNA Replication Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
DNA Replication
DNA Replication Initiation
Pathways
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
G1/S-Specific Transcription
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Drugs
Diseases
Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS
Plasma parathyroid hormone levels (
30134803
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
23 interacting genes:
CDC45
CDC5L
CDC6
CDC7
CDK2
CDT1
DBF4
GOLGA2
GOLGA6L9
KAT7
MCM2
MCM4
MCM5
MCM6
MCM7
ORC2
ORC3
ORC4
ORC5
RB1
RPA2
SKP2
XPO1
28 interacting genes:
CDC45
CDC5L
CDC6
CDK2
CDT1
CTNNA3
DBF4
EP300
H3-4
H4-16
KAT7
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM7
ORC1
ORC3
ORC4
ORC5
ORC6
RAD18
RIPPLY3
RPA1
RPA2
XRCC5
Entrez ID
4998
4999
HPRD ID
03544
03112
Ensembl ID
ENSG00000085840
ENSG00000115942
Uniprot IDs
B7Z8H0
Q13415
Q96F82
A0A024R411
Q13416
PDB IDs
5UJ7
5UJM
6P3W
7JPO
7JPP
7JPR
7JPS
5C8H
5UJ8
5UJM
7JPO
7JPP
7JPQ
7JPR
7JPS
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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