ATP2A2 and CHRM5

Data Source:
BioGRID (two hybrid)

		ATP2A2	CHRM5
Description		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	cholinergic receptor muscarinic 5
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Vesicle Membrane Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Apical Ectoplasmic Specialization Ribbon Synapse Plasma Membrane Bounded Cell Projection	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Calcium Ion Binding Protein Binding ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism ATPase Activity Enzyme Binding Lutropin-choriogonadotropic Hormone Receptor Binding Ion Channel Binding S100 Protein Binding Calcium-transporting ATPase Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis ER-nucleus Signaling Pathway Organelle Organization Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Lipopolysaccharide T-tubule Organization Ion Transmembrane Transport Cellular Response To Oxidative Stress Cellular Response To Heat Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Receptor Binding Proton Transmembrane Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum	Gastric Acid Secretion G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs		Desflurane Istaroxime	Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases		Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glucose homeostasis traits ( 25524916) Protein quantitative trait loci ( 18464913) QT interval ( 24952745 29874175) Schizophrenia ( 28991256 25056061 29483656 30285260) Waist circumference ( 28552196)	Malaria ( 31844061)
Interacting Genes		13 interacting genes: BCL2 CAMK2A CCR4 CHRM5 F2RL1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 TRIM14	31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33
Entrez ID		488	1133
HPRD ID		00161	00331
Ensembl ID		ENSG00000174437	ENSG00000184984
Uniprot IDs		A0A0S2Z3L2 P16615	A0A024R9I2 P08912 Q8IVW0
PDB IDs		5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2	6OL9
Enriched GO Terms of Interacting Partners?
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