ATP2A2 and CAMK2A

Data Source:
HPRD (in vivo, in vitro)

		ATP2A2	CAMK2A
Description		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	calcium/calmodulin dependent protein kinase II alpha
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Vesicle Membrane Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Apical Ectoplasmic Specialization Ribbon Synapse Plasma Membrane Bounded Cell Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Endocytic Vesicle Membrane Neuron Projection Dendritic Spine
	Molecular Function	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Calcium Ion Binding Protein Binding ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism ATPase Activity Enzyme Binding Lutropin-choriogonadotropic Hormone Receptor Binding Ion Channel Binding S100 Protein Binding Calcium-transporting ATPase Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis ER-nucleus Signaling Pathway Organelle Organization Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Lipopolysaccharide T-tubule Organization Ion Transmembrane Transport Cellular Response To Oxidative Stress Cellular Response To Heat Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Receptor Binding Proton Transmembrane Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Angiotensin-activated Signaling Pathway Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Dendritic Spine Development Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Desflurane Istaroxime	Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases		Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glucose homeostasis traits ( 25524916) Protein quantitative trait loci ( 18464913) QT interval ( 24952745 29874175) Schizophrenia ( 28991256 25056061 29483656 30285260) Waist circumference ( 28552196)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Ulcerative colitis ( 28067908)
Interacting Genes		13 interacting genes: BCL2 CAMK2A CCR4 CHRM5 F2RL1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 TRIM14	87 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CAMK2B CAMK2D CAMK2G CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 EGFR ETS1 FAM168A FAM168B GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SQSTM1 SRF SUOX SYNGAP1 TAB2 TANC1 TCAF1 TEX37 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32
Entrez ID		488	815
HPRD ID		00161	06532
Ensembl ID		ENSG00000174437	ENSG00000070808
Uniprot IDs		A0A0S2Z3L2 P16615	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2	2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P
Enriched GO Terms of Interacting Partners?
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