NFKB2 and NKRF

Data Source:
HPRD (in vitro)

		NFKB2	NKRF
Description		nuclear factor kappa B subunit 2	NFKB repressing factor
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Binding Protein Binding
	Biological Process	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection
Drugs		Donepezil Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2	12 interacting genes: ADARB1 DHX15 DHX58 HMOX2 KIFC1 NFKB1 NFKB2 PRKRA REL RELA STAU1 ZNF346
Entrez ID		4791	55922
HPRD ID		01239	02341
Ensembl ID		ENSG00000077150	ENSG00000186416
Uniprot IDs		Q00653	A3F769 O15226
PDB IDs		1A3Q 2D96 3DO7 4OT9 5ZMC	6SH6 6SH7
Enriched GO Terms of Interacting Partners?
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