NFKB2 and GLG1

Data Source:
HPRD (in vitro)

		NFKB2	GLG1
Description		nuclear factor kappa B subunit 2	golgi glycoprotein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex	Golgi Membrane Golgi Apparatus Cytoskeleton Plasma Membrane Membrane Integral Component Of Membrane Extracellular Matrix Extracellular Exosome Postsynaptic Golgi Apparatus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Fibroblast Growth Factor Binding
	Biological Process	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Negative Regulation Of Protein Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Leukocyte Migration Bone Morphogenesis
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection	Cell surface interactions at the vascular wall
Drugs		Donepezil Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Basophil count ( 32888494) Breast cancer ( 18463975) General risk tolerance (MTAG) ( 30643258) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plasma anti-thyroid peroxidase levels ( 29678681) Testicular germ cell tumor ( 23666239) White blood cell count ( 32888494)
Interacting Genes		36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2	4 interacting genes: MTDH NFKB2 SELE UBC
Entrez ID		4791	2734
HPRD ID		01239	02855
Ensembl ID		ENSG00000077150	ENSG00000090863
Uniprot IDs		Q00653	Q92896
PDB IDs		1A3Q 2D96 3DO7 4OT9 5ZMC
Enriched GO Terms of Interacting Partners?
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