NFKB2 and TSC22D3

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		NFKB2	TSC22D3
Description		nuclear factor kappa B subunit 2	TSC22 domain family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Ion Transmembrane Transport Negative Regulation Of Activation-induced Cell Death Of T Cells
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection	Stimuli-sensing channels
Drugs		Donepezil Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2	14 interacting genes: BRME1 DCLK2 FOS HPCAL4 JUN MAD1L1 MTA2 NFKB1 NFKB2 PLEKHF2 RAF1 REL RELA SUMO1
Entrez ID		4791	1831
HPRD ID		01239	04266
Ensembl ID		ENSG00000077150	ENSG00000157514
Uniprot IDs		Q00653	Q5JRJ2 Q99576
PDB IDs		1A3Q 2D96 3DO7 4OT9 5ZMC
Enriched GO Terms of Interacting Partners?
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