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NBN and FANCD2
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
NBN
FANCD2
Description
nibrin
FA complementation group D2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
Cytosol
PML Body
Mre11 Complex
Site Of Double-strand Break
Nuclear Inclusion Body
Condensed Chromosome
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nuclear Body
Molecular Function
Damaged DNA Binding
Protein Binding
Transcription Factor Binding
Protein N-terminus Binding
Protein Binding
DNA Polymerase Binding
Biological Process
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Blastocyst Growth
DNA Replication
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle Arrest
Mitotic G2 DNA Damage Checkpoint
Cell Population Proliferation
Viral Process
Regulation Of DNA-dependent DNA Replication Initiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Telomeric 3' Overhang Formation
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Telomere Maintenance
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Signal Transduction In Response To DNA Damage
Isotype Switching
Neuromuscular Process Controlling Balance
Meiotic Cell Cycle
T-circle Formation
Telomere Maintenance Via Telomere Trimming
Intrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Telomere Capping
Homologous Chromosome Pairing At Meiosis
Gamete Generation
Response To Gamma Radiation
Intra-S DNA Damage Checkpoint
Cellular Response To Oxidative Stress
Interstrand Cross-link Repair
Regulation Of Regulatory T Cell Differentiation
Brain Morphogenesis
Regulation Of Inflammatory Response
Regulation Of DNA-binding Transcription Factor Activity
Neuronal Stem Cell Population Maintenance
Double-strand Break Repair Involved In Meiotic Recombination
Regulation Of CD40 Signaling Pathway
Pathways
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Fanconi anemia
GWAS
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Alzheimer's disease (
24755620
)
Waist-to-hip ratio adjusted for BMI (
28552196
)
Interacting Genes
35 interacting genes:
ATF2
ATM
ATR
BAP1
BRCA1
CASC3
CCNE1
CDK9
CHEK2
DCLRE1C
EP300
FANCD2
H2AX
H3-4
HIF1A
MDC1
MRE11
NAT2
NCL
PRKDC
RAD18
RAD50
RAD51
RECQL5
SIRT1
SNAI1
SUMO2
TERF1
TLK1
TREX1
UBE2D1
UBE2N
VRK1
XRCC4
XRCC5
28 interacting genes:
ATM
ATR
BLM
BRCA1
BRCA2
BRIP1
FANCC
FANCE
FANCI
FANCL
H2AC4
H2BC3
H3C1
H4C1
MEN1
MRE11
NBN
PCNA
RAD51
TERF1
TNFRSF1A
TNFRSF1B
TNKS
UBB
UBE2T
UHRF1
UHRF2
USP1
Entrez ID
4683
2177
HPRD ID
04050
01968
Ensembl ID
ENSG00000104320
ENSG00000144554
Uniprot IDs
A0A0C4DG07
O60934
Q9BXW9
PDB IDs
5WQD
6VAA
6VAD
6VAE
6VAF
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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