AFF1 and SASH1

Data Source:
BioGRID (two hybrid)

		AFF1	SASH1
Description		AF4/FMR2 family member 1	SAM and SH3 domain containing 1
Image
GO Annotations	Cellular Component	Transcription Elongation Factor Complex Super Elongation Complex	Cytoplasm Protein-containing Complex
	Molecular Function	Protein Binding	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Gene Expression	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination
Pathways
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010 32888494 27863252) Hematological and biochemical traits ( 31902109) Hemoglobin ( 29403010 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 32154731 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 30275531 25961943 20686565) White blood cell count (basophil) ( 29403010 27863252)	Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		9 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9	26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
Entrez ID		4299	23328
HPRD ID		08871	06408
Ensembl ID		ENSG00000172493	ENSG00000111961
Uniprot IDs		B4DJU9 P51825 Q14C88	O94885
PDB IDs		2LM0	2DL0 2EBP
Enriched GO Terms of Interacting Partners?
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