MEP1B and NPY

Data Source:
HPRD (in vitro)

		MEP1B	NPY
Description		meprin A subunit beta	neuropeptide Y
Image
GO Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane Meprin A Complex	Extracellular Region Extracellular Space Golgi Apparatus Synapse Neuronal Dense Core Vesicle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding Identical Protein Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Proteolysis Inflammatory Response Toxin Transport	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Intestinal Epithelial Cell Differentiation
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Phentermine 2-aminoisobutyric acid L-tyrosinamide
Diseases
GWAS		Metabolite levels ( 23823483) TRAIL levels ( 27989323)	Adult body size ( 32376654) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Vitamin D levels ( 25208829)
Interacting Genes		12 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT	16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2
Entrez ID		4225	4852
HPRD ID		02667	01214
Ensembl ID		ENSG00000141434	ENSG00000122585
Uniprot IDs		J3QKX5 Q16820	A4D158 P01303
PDB IDs		4GWM 4GWN	1QFA 1RON
Enriched GO Terms of Interacting Partners?
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