MEP1B and GCG

Data Source:
HPRD (in vitro)

		MEP1B	GCG
Description		meprin A subunit beta	glucagon
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GO Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane Meprin A Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding Identical Protein Binding	Signaling Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding
	Biological Process	Proteolysis Inflammatory Response Toxin Transport	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Response To Activity Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis
Pathways			Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) TRAIL levels ( 27989323)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		12 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT	7 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B
Entrez ID		4225	2641
HPRD ID		02667	00676
Ensembl ID		ENSG00000141434	ENSG00000115263
Uniprot IDs		J3QKX5 Q16820	P01275
PDB IDs		4GWM 4GWN	1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6LMK 6LML 6NZN 6PHI 6PHJ 6PHK 6PHL 6PHO 6PHP 6VCB 6X18
Enriched GO Terms of Interacting Partners?
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