HSPA2 and TRIM38

Data Source:
BioGRID (two hybrid)

		HSPA2	TRIM38
Description		heat shock protein family A (Hsp70) member 2	tripartite motif containing 38
Image			No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle	Cellular_component Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding Glycolipid Binding Disordered Domain Specific Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Positive Regulation Of ATPase Activity Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway
Pathways		Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase	Interferon gamma signaling
Drugs		Quercetin
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: APP BAG4 CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38	30 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP STXBP1 TCEA2 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764
Entrez ID		3306	10475
HPRD ID		07174	15555
Ensembl ID		ENSG00000126803	ENSG00000112343
Uniprot IDs		A0A024R6B5 P54652	A0A024QZY4 O00635
PDB IDs		3I33 4FSV 5FPD 5FPE 5FPM 5FPN
Enriched GO Terms of Interacting Partners?
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