RCAN1 and USP22

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RCAN1	USP22
Description		regulator of calcineurin 1	ubiquitin specific peptidase 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	SAGA Complex Nucleoplasm SAGA-type Complex
	Molecular Function	Nucleic Acid Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Coactivator Activity
	Biological Process	Calcium-mediated Signaling Calcineurin-NFAT Signaling Cascade Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle
Pathways			HATs acetylate histones Ub-specific processing proteases
Drugs		Dipyridamole
Diseases
GWAS		Cancer ( 29299148) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		8 interacting genes: APP BTRC GSK3B MAP3K3 MAPK3 PPP3CA USP22 UXT	17 interacting genes: AASDHPPT ATXN7 ATXN7L3 BAG4 CD274 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MTUS2 MYC PSME1 PTGS2 RCAN1 SCFD1 UBC
Entrez ID		1827	23326
HPRD ID		04226	19411
Ensembl ID		ENSG00000159200	ENSG00000124422
Uniprot IDs		B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9	Q9UPT9
PDB IDs		6UUQ
Enriched GO Terms of Interacting Partners?
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