STK3 and PEX19

Data Source:
BioGRID (two hybrid)

		STK3	PEX19
Description		serine/threonine kinase 3	peroxisomal biogenesis factor 19
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Brush Border Membrane Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-terminus Binding ATPase Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Transmembrane Transport Chaperone-mediated Protein Folding Chaperone-mediated Protein Transport Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding
Pathways		Signaling by Hippo	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs		Fostamatinib
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		40 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MARK2 MBP MOB1B MOB3B MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 RASSF2 RASSF4 SAV1 SLMAP SNIP1 STK4 SULT2A1 TFPT TRAF1 ZC3H7A	38 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 MFSD5 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2
Entrez ID		6788	5824
HPRD ID		05433	02610
Ensembl ID		ENSG00000104375	ENSG00000162735
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	A0A0S2Z497 P40855
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2	2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?
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