LSS and CIB1

Data Source:
BioGRID (two hybrid)

		LSS	CIB1
Description		lanosterol synthase	calcium and integrin binding 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Dendrite Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity	Calcium Ion Binding Protein Binding Protein C-terminus Binding Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Protein-membrane Adaptor Activity Ion Channel Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		R048-8071 Lanosterol	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		White blood cell count ( 27863252)
Interacting Genes		9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	37 interacting genes: AURKB CALCB CD27 CDK4 CEACAM6 EIF4G1 ELAPOR1 EXOSC10 FEZ1 FUCA1 GLIS3 IFI6 ITGA2B LSS NBR1 NCK2 NME4 NRIP1 ONECUT3 PAX3 PAX7 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 SCAF1 SSX7 TERT TMEM95 TSGA10IP UBR5 WAS ZBTB49 ZDHHC17
Entrez ID		4047	10519
HPRD ID		02945	03800
Ensembl ID		ENSG00000160285	ENSG00000185043
Uniprot IDs		B2R694 P48449	A0A140VK09 Q99828
PDB IDs		1W6J 1W6K	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5 6OCX 6OD0
Enriched GO Terms of Interacting Partners?
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