CIB1 and NRIP1

Data Source:
BioGRID (two hybrid)

		CIB1	NRIP1
Description		calcium and integrin binding 1	nuclear receptor interacting protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Dendrite Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Histone Deacetylase Complex Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding Protein C-terminus Binding Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Protein-membrane Adaptor Activity Ion Channel Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Retinoid X Receptor Binding
	Biological Process	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Circadian Rhythm Lipid Storage Circadian Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways			SUMOylation of transcription cofactors Circadian Clock Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
Diseases
GWAS			Alcohol dependence ( 26365420) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163) Breast cancer ( 29059683 23535729) Chronic kidney disease ( 31152163) Cognitive performance ( 19734545) Crohn's disease ( 25489960) Depression in smokers ( 30219690) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		37 interacting genes: AURKB CALCB CD27 CDK4 CEACAM6 EIF4G1 ELAPOR1 EXOSC10 FEZ1 FUCA1 GLIS3 IFI6 ITGA2B LSS NBR1 NCK2 NME4 NRIP1 ONECUT3 PAX3 PAX7 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 SCAF1 SSX7 TERT TMEM95 TSGA10IP UBR5 WAS ZBTB49 ZDHHC17	56 interacting genes: ACTN2 AGR2 AHR APP AR ARPC3 BHLHB9 BRCA1 CCDC85B CDK8 CEP70 CIB1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B E2F1 ESR1 ESR2 ESRRA ESRRB ESRRG HDAC1 HDAC2 HDAC3 HDAC5 HNF4A JUN KAT2B LDOC1 MAP3K7 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 PKNOX2 PPARA PPARD PPARG PRMT1 RARA RORB RXRA RXRB TEX11 THRA THRB TNFRSF14 TRAF2 TULP3 VDR YWHAH
Entrez ID		10519	8204
HPRD ID		03800	03927
Ensembl ID		ENSG00000185043	ENSG00000180530
Uniprot IDs		A0A140VK09 Q99828	A8K171 P48552
PDB IDs		1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5 6OCX 6OD0	2GPO 2GPP 4S14 4S15 5NTI 5NTN 5NTW 5NU1 6FZU 6G05 6G07
Enriched GO Terms of Interacting Partners?
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