LSS and YIF1A

Data Source:
BioGRID (two hybrid)

		LSS	YIF1A
Description		lanosterol synthase	Yip1 interacting factor homolog A, membrane trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Integral Component Of Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity	Protein Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport IRE1-mediated Unfolded Protein Response
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	XBP1(S) activates chaperone genes
Drugs		R048-8071 Lanosterol
Diseases
GWAS		White blood cell count ( 27863252)	Bipolar disorder ( 21926972 31043756) Glucose homeostasis traits ( 25524916)
Interacting Genes		9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	72 interacting genes: APOA5 AQP6 BNIP2 C4orf3 CD79A CDK2AP2 CERS2 CNRIP1 CST6 EBP ELOVL4 ERGIC3 FAM210B FARS2 FCER1G FFAR2 GAS7 GJA8 GPR37 GPR42 GPX8 HSD17B11 JOSD2 LNPK LSS MARCHF5 MGST3 MIEF2 MLLT1 MMGT1 MSMO1 MTERF3 MYG1 NDRG4 PLEKHF2 PPIF PTGES PTPN9 RBFA REEP2 REEP4 RIC3 RNF144A SCN3B SCN4B SDCBP SEC23IP SLC10A1 SLC34A1 SLC35C2 SNX10 SNX11 SNX2 SYTL2 SYTL5 TIMMDC1 TMEM139 TMEM14B TMEM17 TMEM225B TMEM248 TMEM31 TMX2 VKORC1 VMA21 WDFY2 YIPF4 YIPF5 ZDHHC16 ZDHHC17 ZFYVE21 ZFYVE27
Entrez ID		4047	10897
HPRD ID		02945	06755
Ensembl ID		ENSG00000160285	ENSG00000174851
Uniprot IDs		B2R694 P48449	A6NGW1 A8K509 O95070
PDB IDs		1W6J 1W6K
Enriched GO Terms of Interacting Partners?
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