RND3 and ARHGAP5

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (in vitro, two hybrid, in vivo)

		RND3	ARHGAP5
Description		Rho family GTPase 3	Rho GTPase activating protein 5
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding
	Biological Process	Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization	Cell Adhesion Rho Protein Signal Transduction Mammary Gland Development Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle
Drugs		Guanosine-5'-Triphosphate
Diseases
GWAS		Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)	Asthma ( 29273806)
Interacting Genes		8 interacting genes: ARHGAP5 C14orf119 CIT CPLANE2 PLXNB1 ROCK1 SKP2 UBXN11	11 interacting genes: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2
Entrez ID		390	394
HPRD ID		04233	04060
Ensembl ID		ENSG00000115963	ENSG00000100852
Uniprot IDs		B2R838 P61587	Q13017
PDB IDs		1M7B 2V55 4BG6	2EE4 2EE5 5U4V
Enriched GO Terms of Interacting Partners?
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