KRT16 and CYTH4

Data Source:
BioGRID (two hybrid)

		KRT16	CYTH4
Description		keratin 16	cytohesin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Intermediate Filament Extracellular Exosome	Golgi Membrane Cytosol Plasma Membrane Centriolar Satellite Intercellular Bridge
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Aging Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Keratinocyte Migration Establishment Of Skin Barrier Cornification	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Keratinization Formation of the cornified envelope	Intra-Golgi traffic
Drugs		Zinc Zinc acetate
Diseases		Non-epidermolytic palmoplantar keratoderma (NEPPK) Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS			Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Uterine fibroids ( 28836065)
Interacting Genes		56 interacting genes: AMOT ARFIP2 C1orf109 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 EPM2AIP1 GAS8 GNG10 HGS KIFC3 KLC4 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1	24 interacting genes: AMOTL2 CBY2 CCDC120 CCDC197 CCDC6 CNKSR1 CTAG1A CTAG1B FOS FOSB HOOK2 IPCEF1 KANK2 KIFC3 KRT15 KRT16 KRT34 KRT40 PCM1 PSMB1 SNAPC5 SYCE1L TRIM54 USHBP1
Entrez ID		3868	27128
HPRD ID		01018	07354
Ensembl ID		ENSG00000186832	ENSG00000100055
Uniprot IDs		P08779	B4E2V8 Q9UIA0
PDB IDs
Enriched GO Terms of Interacting Partners?
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