KRTAP5-9 and ADAM12

Data Source:
BioGRID (two hybrid)

		KRTAP5-9	ADAM12
Description		keratin associated protein 5-9	ADAM metallopeptidase domain 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Epidermis Development Keratinization	Proteolysis Cell Adhesion Myoblast Fusion Extracellular Matrix Organization Positive Regulation Of Angiogenesis
Pathways		Keratinization	Signaling by EGFR Invadopodia formation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Interacting Genes		196 interacting genes: ABHD17A ADAM12 ADAMTSL4 ADAMTSL5 ALDH3B1 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CHRNG CKS1B CNNM3 COL8A1 COMT CRCT1 CREB5 CRH CRY2 CTNNBIP1 CTSZ CXCL16 CYSRT1 DCDC2 DHRS1 DMRT3 DNASE1L3 DOCK2 EMC7 ENKD1 ENPP7 FAH FAM124B FAM161A FAM74A4 FAM76B FLT3LG GGN GLP1R GLRX3 GNE GRN GSC2 HEY2 HHEX HLCS HOXA1 HOXB9 HPCAL1 HSD3B7 HSPD1 IGFBP6 JOSD1 KLHL38 KLK8 KPRP KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 LY6H MAPKBP1 MEOX2 MOBP MT1M NAXD NBPF19 NCLN NECTIN2 NECTIN3 NKD1 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NR4A3 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 P2RY6 P4HB PCSK5 PDE9A PFKL PGAP6 PGLS PHLDA1 PIN1 POM121L8P POTEB3 POU4F2 PRKAB2 PSMA1 PTPMT1 RAMP3 RASD1 RGS20 RNF111 SCARB1 SCNM1 SDC3 SDCBP SEMA3B SHFL SLC13A5 SLC15A3 SLC22A23 SLC25A10 SMCP SPATA3 SPATC1L SPG7 SPINK2 SPRY1 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TGM1 TOMM22 TRARG1 TYRO3 UBE2I UXT VWC2 WNT11 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF581 ZNF587 ZNF655 ZNF696 ZNF837	40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1
Entrez ID		3846	8038
HPRD ID		01008	04092
Ensembl ID		ENSG00000254997	ENSG00000148848
Uniprot IDs		P26371	A8K6G4 O43184 U5NE98
PDB IDs
Enriched GO Terms of Interacting Partners?
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