KRTAP5-9 and NR4A3

Data Source:
BioGRID (two hybrid)

		KRTAP5-9	NR4A3
Description		keratin associated protein 5-9	nuclear receptor subfamily 4 group A member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity
	Biological Process	Epidermis Development Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Gastrulation Pyruvate Oxidation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glucose Transmembrane Transport Intracellular Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Mast Cell Cytokine Production Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Mast Cell Degranulation Steroid Hormone Mediated Signaling Pathway Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Positive Regulation Of Monocyte Aggregation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior
Pathways		Keratinization	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs			Dasatinib
Diseases			Extraskeletal myxoid chondrosarcoma
GWAS			Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424)
Interacting Genes		196 interacting genes: ABHD17A ADAM12 ADAMTSL4 ADAMTSL5 ALDH3B1 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CHRNG CKS1B CNNM3 COL8A1 COMT CRCT1 CREB5 CRH CRY2 CTNNBIP1 CTSZ CXCL16 CYSRT1 DCDC2 DHRS1 DMRT3 DNASE1L3 DOCK2 EMC7 ENKD1 ENPP7 FAH FAM124B FAM161A FAM74A4 FAM76B FLT3LG GGN GLP1R GLRX3 GNE GRN GSC2 HEY2 HHEX HLCS HOXA1 HOXB9 HPCAL1 HSD3B7 HSPD1 IGFBP6 JOSD1 KLHL38 KLK8 KPRP KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 LY6H MAPKBP1 MEOX2 MOBP MT1M NAXD NBPF19 NCLN NECTIN2 NECTIN3 NKD1 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NR4A3 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 P2RY6 P4HB PCSK5 PDE9A PFKL PGAP6 PGLS PHLDA1 PIN1 POM121L8P POTEB3 POU4F2 PRKAB2 PSMA1 PTPMT1 RAMP3 RASD1 RGS20 RNF111 SCARB1 SCNM1 SDC3 SDCBP SEMA3B SHFL SLC13A5 SLC15A3 SLC22A23 SLC25A10 SMCP SPATA3 SPATC1L SPG7 SPINK2 SPRY1 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TGM1 TOMM22 TRARG1 TYRO3 UBE2I UXT VWC2 WNT11 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF581 ZNF587 ZNF655 ZNF696 ZNF837	43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330
Entrez ID		3846	8013
HPRD ID		01008	02766
Ensembl ID		ENSG00000254997	ENSG00000119508
Uniprot IDs		P26371	A0A024R168 Q92570
PDB IDs
Enriched GO Terms of Interacting Partners?
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