ADAM12

Description		ADAM metallopeptidase domain 12
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Extracellular Matrix Organization Positive Regulation Of Angiogenesis
Pathways		Signaling by EGFR Invadopodia formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Novel Interacting Genes		2 novel interacting genes: DOCK1 TUBGCP2
Interacting Genes		40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1
Entrez ID		8038
HPRD ID		04092
Ensembl ID		ENSG00000148848
Uniprot IDs		A8K6G4 O43184 U5NE98
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?