ADAM12 and FSTL3

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ADAM12	FSTL3
Description		ADAM metallopeptidase domain 12	follistatin like 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Nucleus Nucleoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Neuron Projection Terminus
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Fibronectin Binding Protein Binding Activin Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Extracellular Matrix Organization Positive Regulation Of Angiogenesis	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Adrenal Gland Development Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		Signaling by EGFR Invadopodia formation	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)	Nickel levels ( 26025379)
Interacting Genes		40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1	5 interacting genes: ADAM12 FN1 INHBA MSTN SMAD4
Entrez ID		8038	10272
HPRD ID		04092	05632
Ensembl ID		ENSG00000148848	ENSG00000070404
Uniprot IDs		A8K6G4 O43184 U5NE98	A0A024R1Y8 O95633
PDB IDs			2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?
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