TSEN54 and TSEN2

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid)

		TSEN54	TSEN2
Description		tRNA splicing endonuclease subunit 54	tRNA splicing endonuclease subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus Centrosome Cytosol
	Molecular Function	Protein Binding	TRNA-intron Endonuclease Activity Nucleic Acid Binding Protein Binding Lyase Activity
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		tRNA processing in the nucleus	tRNA processing in the nucleus
Drugs
Diseases		Pontocerebellar hypoplasia	Pontocerebellar hypoplasia
GWAS		Deep white matter hyperintensities ( 32517579) FEV1 ( 30804560) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Platelet count ( 32888494) Plateletcrit ( 32888494) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370)	Systemic lupus erythematosus ( 28714469) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		21 interacting genes: BRCA1 CCDC57 CLP1 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12	7 interacting genes: CADPS CTAG2 GABPB2 RANBP10 TAX1BP1 TEPSIN TSEN54
Entrez ID		283989	80746
HPRD ID		12291	10576
Ensembl ID		ENSG00000182173	ENSG00000154743
Uniprot IDs		Q7Z6J9	A0A024R2G3 Q8NCE0
PDB IDs
Enriched GO Terms of Interacting Partners?
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